Dr Shyam N Gupta · Fertility & IVF Call the clinic

Indira IVF  ·  J.P. Nagar, Bengaluru

DrShyam N Gupta

Fertility & IVF Specialist · Gynaecological Endoscopic Surgeon

MBBS  ·  MD (Obstetrics & Gynaecology)  ·  FIAGE  ·  FMAS

Twelve years in reproductive medicine, much of it spent on the cases that arrive after other cycles have already failed — recurrent implantation failure, recurrent miscarriage, severe male factor infertility. Centre Head at Indira IVF Bengaluru and Zonal Business Director for Indira IVF South.

12+ years in IVF 15,000+ ovum pickups National Fertility Award
Dr Shyam N Gupta, Fertility and IVF Specialist
15,000+
Ovum pickups
10,000+
Embryo transfers
11,000+
Hysteroscopies
2,000+
Laparoscopic surgeries
1,100+
Surgical sperm retrievals
1,000+
Gynaecological procedures
500+
Immunological evaluations & treatment
20+
Microwave ablation for endometriosis

Clinical focus

The problems he is usually asked to solve

Routine IVF is only part of the work. Most referrals concern couples for whom something has already gone wrong more than once, and the question is why.

Recurrent implantation failure

Working through the endometrium, the immune picture and embryo factors when good-quality embryos repeatedly fail to implant, rather than simply transferring again.

How it is investigated →

Recurrent miscarriage & reproductive immunology

Immune evaluation and treatment, including low-dose lymphocyte immunisation therapy with partner lymphocytes — an approach on which he has published live birth outcomes.

Workup and where LIT fits →

Male factor infertility

Surgical sperm retrieval by TESA and PESA for azoospermia and severe oligospermia, followed by ICSI. Formally trained in andrology at ANDROFERT, Brazil.

Azoospermia, TESA and PESA →

IVF, ICSI and IUI

Stimulation planned to the individual rather than to a house protocol — including trial work on decision-support tools that personalise and simplify stimulation.

When IVF is not the first answer →

PCOS and endometriosis

Medical and surgical management of the two conditions that most often sit behind unexplained subfertility in younger patients.

Low AMH and ovarian reserve →

Hysteroscopic & laparoscopic surgery

Fertility-preserving minimal access surgery — septa, adhesions, polyps, fibroids and tubal disease — as a Fellow of the Indian Association of Gynaecological Endoscopists.

Thin and refractory endometrium

Regenerative approaches for a lining that will not respond, including published pilot work on autologous blood cell derivatives in frozen embryo transfer cycles.

High-risk pregnancy & fetal medicine

Antenatal care after assisted conception, supported by advanced fetal medicine training at AIIMS and Maulana Azad Medical College, New Delhi.

Practice & appointments

Where he works, and what he is responsible for

Centre Head & Consultant Fertility Specialist
Indira IVF, J.P. Nagar, Bengaluru — since 2016
Zonal Business Director — South
Indira IVF, covering Karnataka, Andhra Pradesh, Telangana and Tamil Nadu
Faculty, FNB Reproductive Medicine
National Board of Examinations, New Delhi
Committee Member, Special Interest Group — Artificial Intelligence
ASPIRE (Asia Pacific Initiative on Reproduction)
Languages
English, Hindi, Nepali and Bhojpuri; conversational Kannada and Bengali

Professional societies

FOGSI ISAR BSOG IAGE SFM ASPIRE ESHRE ASRM Fetal Medicine Foundation RCOG (UK) — Associate

Profile photographs

Portraits

Press and conference organisers are welcome to use these for programmes, posters and speaker introductions.

Studio portrait of Dr Shyam N Gupta
Studio portrait
Dr Shyam N Gupta in surgical scrubs beside an embryo incubator
In the IVF laboratory
Dr Shyam N Gupta at the Indira IVF centre
At the centre

Qualifications & training

Trained across India, Nepal, Singapore, China and Brazil

Degrees

  • MBBSTribhuvan University, Nepal
  • MD — Obstetrics & GynaecologyB. P. Koirala Institute of Health Sciences
  • MRCOG Part 1Royal College of Obstetricians & Gynaecologists, UK
  • GMHE — Healthcare ManagementIIM Bangalore (IIMB Alumni)

Fellowships & diplomas

  • Advanced Fellowship in InfertilityInfertility Foundation of America (IFA), Udaipur & New Delhi
  • FIAGEIndian Association of Gynaecological Endoscopists
  • FMAS — Minimal Access SurgeryGurugram
  • Diploma in Male InfertilityMeDEA / ANDROFERT, Brazil

Advanced training

  • Reproductive endocrinology & IVFCREST, Singapore
  • Gynaecological laparoscopyAPGET, Guangzhou, China
  • Fetal medicineAIIMS and Maulana Azad Medical College, New Delhi
  • Microwave ablationAPAGE workshop, Shanghai, 2025

Research

Sixteen publications, cited more than 1,300 times

Peer-reviewed work in reproductive immunology, male factor infertility and decision-support for IVF stimulation, presented at ASRM, ESHRE and ASPIRE. Selected papers below, most recent first.

  • 2024 Improving pregnancy success rates: a large multi-centre randomised clinical trial utilising a novel decision support tool Fertility and Sterility 122(4): e351–e352 · doi:10.1016/j.fertnstert.2024.08.097
  • 2024 A new decision-support tool in a multi-centre randomised trial for personalised, optimised and simplified fertility treatment in non-PCOS patients Reproduction and Fertility 5(3) · doi:10.1530/RAF-24-0013
  • 2023 High live birth rates after low-dose lymphocyte immunisation therapy with partner lymphocytes in recurrent miscarriage patients First author · Fertility & Reproduction 5(4) · doi:10.1142/S2661318223743473
  • 2023 Does percutaneous epididymal sperm aspiration attribute as the game changer in high-risk male factor fertility for ICSI? First author · Fertility & Reproduction 5(4): 541 · doi:10.1142/S2661318223742960
  • 2023 Treatment of refractory thin endometrium with an autologous blood cell derivative in frozen embryo transfer cycles: a pilot study Fertility Science and Research 10(3): 151–157 · doi:10.4103/fsr.fsr_28_23
  • 2023 High live birth rates after low-dose immunisation therapy pre- and post-pregnancy with partner lymphocytes in recurrent miscarriage ESHRE abstract P-529 · Human Reproduction 38(Suppl. 1) · doi:10.1093/humrep/dead093.872
  • 2023 IVF stimulation optimised, personalised and simplified using an advanced decision support tool Fertility and Sterility 120(4): e205–e206
  • 2018 Clinicopathological pattern of cervical Papanicolaou smears: a hospital-based experience Janaki Medical College Journal of Medical Science 5(2): 27 · doi:10.3126/jmcjms.v5i2.19014
  • 2017 Effect of early tranexamic acid administration on mortality, hysterectomy and other morbidities in women with post-partum haemorrhage (WOMAN trial) WOMAN Trial Collaborators · The Lancet 389(10084): 2105–2116 · doi:10.1016/S0140-6736(17)30638-4
  • 2012 Maternal and fetal outcome in term labour with meconium-stained amniotic fluid Health Renaissance 10(3): 198–202 · doi:10.3126/hren.v10i3.7135

Trials in progress

  • Can luteal phase support be stopped at eight weeks' gestation in HRT frozen embryo transfer? A randomised controlled trial with Prof. Peter Humaidan
  • Pre-eclampsia following natural versus artificial cycle frozen embryo transfer. A randomised controlled trial with Prof. Nikolaos P. Polyzos
  • ART outcomes with 0.2 mg GnRH agonist trigger versus dual trigger in women with poor ovarian reserve. A randomised clinical trial with Dr Kshitiz Murdia

Recognition

Awards, honours and research grants

  • 2026Indira IVF Leadership AwardIndira IVF Hospital Pvt Ltd
  • 2026Top 25 Most Trusted Gynaecologists and IVF Specialists in IndiaAIM Award
  • 2026Best IVF Clinic in South IndiaNational Fertility Award
  • 2024 · 2025Most Dynamic IVF Specialist in South IndiaGolden AIM Global Awards, Dubai
  • 2024Most Iconic Healthcare LeaderGolden Star Award
  • 2022 – 2025Best IVF Specialist (South) and Best Budding Endoscopic Surgeon (South)National Fertility Award, four consecutive years
  • 2023Leadership AwardIndira IVF Hospital Pvt Ltd
  • 2013Research grant, 9th Singapore International Congress of Obstetrics & GynaecologySingapore
  • 2012Young Researcher grantBinaytara Foundation, USA

Certificates

Congress attendance and credentials

Certificates from congresses, workshops and courses — ESHRE, ASPIRE, ASRM and the fellowship and diploma programmes behind the practice.

ESHRE 39th Annual Meeting, Copenhagen
ESHRE 39th Annual Meeting, Copenhagen2023

Poster presentations

Research presented at congress

Scientific posters presented at ESHRE, ASPIRE and ASRM — reproductive immunology, male factor infertility and endometrial receptivity.

Poster: low-dose lymphocyte immunisation therapy in recurrent implantation failure and recurrent pregnancy loss
Poster: low-dose lymphocyte immunisation therapy in recurrent implantation failure and recurrent pregnancy lossCongress poster presentation

Writing

Notes on where fertility medicine is going

Editorials, reflections from clinic and plain-language explainers, written for colleagues and for the couples who sit across the desk.

Fertility Medicine in 2030: from IVF clinic to intelligent reproductive health systems

Seven shifts that will define the next decade of reproductive medicine — AI-assisted embryology, male fertility moving to centre stage, evidence-based personalisation, fertility preservation, honest outcome reporting, and why trust will remain the strongest medicine.

Read the full pieceClose

When hope refused to give up

A couple, eleven years of marriage, six clinics and two failed IVF cycles — and what their daughter taught me about the part of fertility medicine that never appears in a protocol.

Read the full pieceClose

Advanced fertility care in Bengaluru: services and approach

What each treatment actually involves — natural conception support, infertility workup, IUI, IVF and ICSI, and reproductive immunogenetics for couples with repeated miscarriage or failed cycles.

Read the full pieceClose

Common questions

What couples ask before their first appointment

Straight answers about choosing a fertility specialist in Bengaluru, what happens after a failed cycle, and what to bring to a first consultation.

How do I choose a fertility specialist in J.P. Nagar, Bengaluru?
Look at three things rather than advertising. First, whether the doctor personally handles your kind of case — routine IVF and repeated failure are different problems. Second, whether they publish or teach, which shows the work is examined by peers. Third, whether the first consultation is spent explaining rather than selling. Dr Shyam N Gupta consults at Indira IVF, J.P. Nagar, and takes referrals from across Bengaluru and Karnataka for cases that have already failed elsewhere.
How experienced is Dr Shyam N Gupta?
Twelve years in reproductive medicine. Personally performed over 12,000 ovum pickups, 9,000 embryo transfers, 8,000 hysteroscopic procedures, 1,000 laparoscopic surgeries and 500 surgical sperm retrievals. He is Centre Head at Indira IVF J.P. Nagar and Zonal Business Director for South India, faculty for the FNB in Reproductive Medicine under the National Board of Examinations, and has sixteen peer-reviewed publications cited more than 1,300 times.
My IVF has already failed. What would be done differently?
A failed cycle is a question, not a verdict. Before transferring again the aim is to find the reason: embryo quality and genetics, endometrial receptivity and thickness, the immune picture, undiagnosed male factor such as high DNA fragmentation, and conditions like adenomyosis or chronic endometritis that are easy to miss. Only once there is an explanation does the next protocol get planned — repeating the same cycle and hoping for a different result is rarely the right answer.
What is recurrent implantation failure, and how is it investigated?
It usually means good-quality embryos have failed to implant across several transfers. Investigation covers the uterine cavity by hysteroscopy, chronic endometritis (CD138 testing), endometrial thickness and receptivity, thyroid and metabolic factors, immune and clotting evaluation, and a full re-look at the male side. Dr Gupta has published on GnRH agonist pre-treatment and endometrial CD138 plasma cell density in recurrent implantation failure and adenomyosis.
What is lymphocyte immunisation therapy (LIT), and who is it for?
LIT immunises the woman with her partner's lymphocytes, with the aim of shifting the immune response that may be rejecting the pregnancy. It is considered in selected couples with unexplained recurrent miscarriage after other causes are excluded, not offered routinely. Dr Gupta has published live birth outcomes after low-dose LIT with partner lymphocytes in Fertility & Reproduction, and presented the work at ESHRE. Evidence in recurrent implantation failure remains less settled than in recurrent miscarriage, and that distinction is explained before treatment.
There is no sperm in the semen sample. Is treatment still possible?
Often yes. Azoospermia may be obstructive or non-obstructive, and sperm can frequently be recovered surgically by PESA or TESA and used for ICSI. Around 500 surgical sperm retrievals have been performed at this centre. Dr Gupta holds a Diploma in Male Infertility from ANDROFERT, Brazil, and has published on PESA-retrieved sperm in high-risk male factor ICSI.
Do I need IVF, or would IUI be enough?
IUI can be reasonable with open tubes, adequate sperm and a younger partner, and it is far less invasive. IVF becomes the better route with tubal disease, significant male factor, low ovarian reserve, advanced age, endometriosis, or after IUI has failed several times. The honest answer depends on your tests, not on a general rule — which is why the first consultation is diagnostic rather than prescriptive.
What should I bring to a first consultation?
Everything you already have: previous cycle summaries and discharge notes, semen analyses, hormone profiles including AMH, thyroid and prolactin, HSG or ultrasound reports, hysteroscopy or laparoscopy notes, and details of medication used in earlier cycles. A consultation with the old records in the room is far more productive than one that starts from scratch.
Which conditions does Dr Gupta treat most often?
Recurrent implantation failure, recurrent miscarriage and reproductive immunology, male factor infertility including surgical sperm retrieval, PCOS, endometriosis, thin and refractory endometrium, and fertility-preserving hysteroscopic and laparoscopic surgery. Routine IVF, ICSI and IUI are part of the practice, but most referrals concern couples for whom something has already gone wrong more than once.
How do I book an appointment?
Call or message +91 98999 84791 — the same number takes calls and WhatsApp. Consultations are by appointment at Indira IVF, Woody's Building, 3rd Floor, Plot No. 45/1-1, near Bangalore Central Mall, J.P. Nagar, Bengaluru 560078.

Patients

Rated 4.8 at the centre Dr Gupta leads

Dr Gupta has practised at Indira IVF, J.P. Nagar since 2016 and is Centre Head. This is the centre’s Google rating, earned by the clinical team he leads.

4.8 ★★★★★ 1,439 Google reviews

Indira IVF J.P. Nagar is rated 4.8 out of 5 from more than 1,400 reviews on Google — among the highest-reviewed fertility centres in South Bengaluru. Reviews cover the whole team; a selection mentioning Dr Gupta appears below.

“Met Dr Shyam sir and discussed our previous reports — the experience felt completely different from the very beginning.”

Mohammed V. · Google review, after treatment at three or four other centres

“Our special thanks to Dr Shwetha and Dr Shyam for their guidance, support and positive approach, which kept us hopeful throughout the journey.”

Asha H. · Google review

Reviews are published on Google by patients of Indira IVF, J.P. Nagar and are quoted here in part. See also Dr Gupta’s profile on Indira IVF and his Practo listing.

Follow & review

Updates, and a place to leave feedback

Case notes, congress reports and patient education go out on LinkedIn, Instagram and Facebook. If you have been treated at the centre, a Google review helps other couples decide.

Google reviews

Were you treated at the centre?

Fertility treatment is chosen largely on trust, and couples weighing up a clinic read what other patients have written. If you have been through treatment here, a few honest lines help more than you would think.

Write a Google review Or read what patients have already said about Indira IVF, J.P. Nagar.

From Instagram and Facebook

Each post loads from Instagram or Facebook only when you press play, so neither can track you before you choose to watch.

Instagram reel

ASPIRE 2026, Beijing

Three scientific papers presented and two sessions chaired at the Asia Pacific Initiative on Reproduction congress.

Play reel

Instagram reel

IVF questions, answered

Episode 3 of the FAQ series from Indira IVF J.P. Nagar, for couples still unsure what IVF actually involves.

Play reel

Instagram reel

International Speaker Programme 2025

Prof. Simon Fishel, part of the team behind the first IVF baby, and Dr Sandro Esteves of ANDROFERT, in Bengaluru.

Play reel

Facebook page

Latest posts

The newest updates from the Facebook page, loaded live, so this card is never out of date.

Show posts

Consultations

Booking an appointment

Consultations are by appointment at Indira IVF, J.P. Nagar. Bring any previous cycle summaries, semen analyses, hormone profiles and imaging you already have — the first consultation is far more useful with them in the room.

Dr Shyam N Gupta

Clinic

Indira IVF, J.P. Nagar
Woody's Building, 3rd Floor, Plot No. 45/1-1
Near Bangalore Central Mall, J.P. Nagar
Bengaluru 560078, Karnataka

Appointments & WhatsApp

+91 98999 84791

Same number for calls and WhatsApp

Email

centerhead.bangalore@indiraivf.in

Centre Head’s office, Indira IVF Bengaluru

For colleagues

Speaking, faculty and study collaboration enquiries are welcome through the centre.

Call WhatsApp